Rather than trying to represent the entire world, the "World Beer Museum" narrows its focus to brews from five beer-producing countries - Belgium, Germany, the UK, Czech Republic and the US - along with a "world food" menu of representative dishes from those same countries. Choose from 15-20 beers on draft, or another 150 by the bottle. Prices are a tad higher than average, but not outrageously so, given the location.
US draft beers include a few each from Pike Brewing Company in Seattle and High Water Brewing in California - craft beers not otherwise available in Tokyo. (High Water's Hop Riot IPA is especially recommended.) The food is a cut above typical pub fare - the double cheeseburger (Y1700), served with a tangy barbecue sauce, was filling and quite tasty, and the Czech pork cutlet was also good.
The restaurant itself is huge (some 300 seats), with several different counter bars in addition to table seating, so it should be easier to get a seat here than at some other Skytree destinations. (Note though that reservations can be made only on weekdays.) The atmosphere is lively, with loud music and enthusiastic service. Budget around Y3500 for food and drink; you can also shop at the adjacent retail counter for beers to go.